Senior quarterback Quinn Boyle connected with junior receiver Rory Boos for a 50-yard touchdown pass less than two minutes into the game Friday, and Loyola beat St. Francis 42-7 in Wheaton in a Catholic League crossover.
The Ramblers (3-1) led 42-0 at the half on their way to a third win in a row.
Senior running back Hamid Bullie, senior running back Alec Brownlee and junior running back Tyler Flores all scored rushing TDs.
Junior quarterback Jack Fallon relieved Boyle and went 4-for-7 for 45 yards and two TDs. Senior tight end Charlie Gilroy and senior receiver Andrew Forsyth both caught TDs from Fallon.
Loyola plays at home Saturday against Fenwick.